4610 T3D4556 Guaifenesin An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem] 93-14-1 3516 C10H14O4 198.22 White powder. 78.5-79°C 215 °C at 1.90E+01 mm Hg highly water-soluble Rapidly absorbed from the GI tract Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing. Oral, Rat: LD<sub>50</sub> 1510 mg/kg Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite. Half Life: 1 hour Oral, Rat: LD<sub>50</sub> 1510 mg/kg No indication of carcinogenicity to humans (not listed by IARC). Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections. 2014-08-30T21:03:55Z 2026-08-18T01:10:19Z Guaifenesin DB00874 true COC1=CC=CC=C1OCC(O)CO C10H14O4 InChI=1S/C10H14O4/c1-13-9-4-2-3-5-10(9)14-7-8(12)6-11/h2-5,8,11-12H,6-7H2,1H3 HSRJKNPTNIJEKV-UHFFFAOYSA-N 198.2158 198.089208936 Exogenous Solid 1.39 CHEMBL980 3396 <p>Wilfred P. Shum, Harry Mazurek, Jian Chen, &#8220;Process for producing enantiomerically enriched guaifenesin.&#8221; U.S. Patent US5495052, issued August, 1949.</p> CHEM003516 DTXSID5023114 NS00007812 3-(2-methoxyphenoxy)propane-1,2-diol 58.92 51.239200000000004 20.591929766068017 5 4 2 13.624144565278591 -2.968617563618232 0 1 0.76 -1.12 1.49e+01 g/l Organic compounds Benzenoids Phenol ethers Anisoles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 ï¾­Þ������������������������€���`�������(������@(������@h�������@h�������@h�������@h�������@(�������(�������`�������`�������`�������`�������`����������� ��h���h���h���h���h��� � � � �� ��� ���h�B��������������������� 2026-09-19T04:01:21Z