4611 T3D4557 Desloratadine Desloratadine is a second generation, tricyclic antihistamine that which has a selective and peripheral H1-antagonist action. It is the active descarboethoxy metabolite of loratidine (a second generation histamine). Desloratidine has a long-lasting effect and does not cause drowsiness because it does not readily enter the central nervous system. 100643-71-8 124087 C19H19ClN2 White powder. Like other H1-blockers, Desloratadine competes with free histamine for binding at H<sub>1</sub>-receptors in the GI tract, uterus, large blood vessels, and bronchial smooth muscle. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by histamine. Route of Elimination: Desloratadine (a major metabolite of loratadine) is extensively metabolized to 3-hydroxydesloratadine, an active metabolite, which is subsequently glucuronidated. Approximately 87% of a 14C-desloratadine dose was equally recovered in urine and feces. Half Life: 50 hours No indication of carcinogenicity to humans (not listed by IARC). For the relief of symptoms of seasonal allergic rhinitis, perennial (non-seasonal) allergic rhinitis. Desloratidine is also used for the sympomatic treatment of pruritus and urticaria (hives) associated with chronic idiopathic urticaria. 2014-08-30T21:04:00Z 2026-05-14T16:54:25Z Desloratadine 291342 DB00967 true ClC1=CC2=C(C=C1)C(=C1CCNCC1)C1=C(CC2)C=CC=N1 C19H19ClN2 InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2 JAUOIFJMECXRGI-UHFFFAOYSA-N 310.821 310.123676325 Exogenous Solid 3.2 CHEMBL1172 110575 <p>Zoltan Toth, &#8220;Processes for preparation of polymorphic forms of desloratadine.&#8221; U.S. Patent US20040242619, issued December 02, 2004.</p> CHEM003517 DTXSID1044196 NS00008826 13-chloro-2-(piperidin-4-ylidene)-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-hexaene 24.92 101.03880000000002 34.35062039939022 0 2 1 9.729122040669644 1 4 3.48 -4.90 3.95e-03 g/l