4613 Dimenhydrinate Dimenhydrinate (Dramamine, Gravol and Vertirosan) is an over-the-counter drug used to prevent motion sickness. It is closely related to diphenhydramine HCl, or Benadryl. It is primarily a H1-antagonist, but also possesses an antimuscarinic effect. 523-87-5 441281 C24H28ClN5O3 White powder. 102.5-104°C 3000 mg/L Well absorbed after oral administration. The mechanism by which some antihistamines exert their antiemetic, anti&ndash;motion sickness, and antivertigo effects is not precisely known but may be related to their central anticholinergic actions. They diminish vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Dimenhydrinate is a competitive antagonist at the histamine H1 receptor, which is widely distributed in the human brain. Dimenhydrinate's anti-emetic effect is probably due to H1 antagonism in the vestibular system in the brain. Hepatic (cytochrome P-450 system). Half Life: 1 to 4 hours No indication of carcinogenicity to humans (not listed by IARC). Used for treating vertigo, motion sickness, and nausea associated with pregnancy. Symptoms of overdose include delerium, hallucinations, and excitment. Patients may be violent and confused. 2014-08-30T21:04:18Z 2026-04-13T20:40:07Z Dimenhydrinate 4604 DB00985 true CN1C2=C([N-]C(Cl)=N2)C(=O)N(C)C1=O.C[NH+](C)CCOC(C1=CC=CC=C1)C1=CC=CC=C1 C24H28ClN5O3 InChI=1S/C17H21NO.C7H7ClN4O2/c1-18(2)13-14-19-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16;1-11-4-3(9-6(8)10-4)5(13)12(2)7(11)14/h3-12,17H,13-14H2,1-2H3;1-2H3,(H,9,10,13) DKHVTDUUNTVKOW-UHFFFAOYSA-N 469.964 469.188067494 Exogenous Solid -0.39 CHEMBL1200406 390044 <p>Cusic, J.W.; U.S. Patent 2,499,058; February 28,1950; assigned to G.D. Searle &amp; Co. <br />Cusic, J.W.; U.S. Patent 2,534,813; December 19,1950; assigned to G.D. Searle &amp; Co.</p> CHEM003519 DTXSID9025087 NS00076452 8-chloro-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-7-ide; [2-(diphenylmethoxy)ethyl]dimethylazanium