4674 T3D4620 Urea Urea is a highly soluble organic compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids. Urea is formed in a cyclic pathway known simply as the urea cycle. In this cycle, amino groups donated by ammonia and L-aspartate are converted to urea. Urea is essentially a waste product; it has no physiological function. It is dissolved in blood (in humans in a concentration of 2.5 - 7.5 mmol/liter) and excreted by the kidney in the urine. In addition, a small amount of urea is excreted (along with sodium chloride and water) in human sweat. 57-13-6 1176 CH4N2O 60.056 White powder. 132°C 545.0 mg/mL No indication of carcinogenicity to humans (not listed by IARC). 10% hydrate skin, 15% accelerate fibrin degradation, 20-30% are antipruritic, break down keratin, decrease the thickness of the stratum corneum and are used in scaling conditions such as ichthysosis, and 40% are proteolytic and may be used to dissolve and peel dystrophic nails. 2014-09-05T17:15:01Z 2026-04-17T17:48:06Z Urea C00086 16199 UREA DB03904 URE true NC(N)=O CH4N2O InChI=1S/CH4N2O/c2-1(3)4/h(H4,2,3,4) XSQUKJJJFZCRTK-UHFFFAOYSA-N 60.0553 60.03236276 Endogenous Solid -2.11 HMDB00294 CHEMBL985 1143 <p>Ryo Yoshida, Haruhiko Katoh, Seizo Sumida, Ichiki Takemoto, Junya Takahashi, Katsuzo Kamoshita, &#8220;Urea derivatives, and their production and use.&#8221; U.S. Patent US4334912, issued 0000.</p> CHEM003580 DTXSID4021426 REACH SI00006682 NS00001564 urea