4678 3-Amino-1,4-dimethyl-5H-pyrido [4,3-b]indole 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) is one of the potent food-born dietary carcinogens derived mainly from burnt meat products. The activation of heterocyclic amines, including Trp-P-1, to reactive metabolites is a critical step to exhibit its carcinogenic effects ( Chun et al., 2000, Shiotani et al., 2001 and Kato, 1986). At the initial phase in the carcinogenic process, an exocyclic amino group of Trp-P-1 is metabolically activated to hydroxyamino derivatives by cytochrome P450 to form DNA adducts, which are considered as a main cause of DNA damage during the carcinogenic process in vitro and in vivo ( Shiotani and Ashida, 2004, Inami and Mochizuki, 2002 and Hatanaka et al., 2001). On the other hand, Trp-P-1 can also directly interact with DNA and induces chromosomal aberrations ( Shiotani and Ashida, 2004), suggesting that Trp-P-1 can cause DNA damage without metabolic activation to the N-hydroxyl form. DNA damage triggers not only mutation and carcinogenesis but also apoptosis ( Hashimoto et al., 2004 and Shiotani and Ashida, 2004), indeed 2-acetamidofluorane, a chemical carcinogen with a Trp-P-1-related structure, shows a cytotoxic effect on hepatocytes ( Ashida et al., 1998) and induced apoptosis in the rat liver in vivo. 62450-06-0 5284474 C13H13N3 White powder. 252 - 262 °C 2B, possibly carcinogenic to humans. (L135) 2014-09-08T02:38:09Z 2016-11-09T01:09:10Z C19306 true CC1=C2C(NC3=CC=CC=C23)=C(C)C(N)=N1 C13H13N3 InChI=1S/C13H13N3/c1-7-12-11(8(2)15-13(7)14)9-5-3-4-6-10(9)16-12/h3-6,16H,1-2H3,(H2,14,15) LVTKHGUGBGNBPL-UHFFFAOYSA-N 211.2624 211.110947431 Exogenous Solid HMDB29746 4447538 CHEM003584 1,4-dimethyl-5H-pyrido[4,3-b]indol-3-amine