4701 Loprazolam Loprazolam is an exogenous organic compound with the formula C23H21ClN6O3 and an average molecular weight of 464.90 g/mol. It exists as a solid at room temperature. Loprazolam belongs to the 1,4-benzodiazepines, a subclass of benzodiazepines within the organic compounds. Marketed under the brand names Dormonoct, Havlane, Sonin, and Somnovit, this drug is an imidazole benzodiazepine derivative used for the short-term treatment of moderately severe insomnia. It is available in 2 mg and 1 mg tablets and possesses sedative, anxiolytic, anticonvulsant, and skeletal muscle relaxant properties. The compound acts on 20 recorded protein targets, serving as a positive allosteric modulator of the Translocator protein (TSPO), Gamma-aminobutyric acid receptor subunit alpha-1 (GABRA1), Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2), Gamma-aminobutyric acid receptor subunit alpha-3 (GABRA3), and 16 other proteins. Loprazolam has been found in or released from two recorded sources: Household cleaning & consumer products (Non Electric Simulated Smoking Devices) and Electrical & Electronic Equipment (Antennas). 61197-73-7 3033860 C23H21ClN6O3 464.9 White powder. Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. No indication of carcinogenicity to humans (not listed by IARC). Loprazolam is licensed and marketed for the short term treatment of moderately severe insomnia. General supportive measures should be employed, along with intravenous fluids, and an adequate airway maintained. Hypotension may be combated by the use of norepinephrine or metaraminol. Dialysis is of limited value. Flumazenil (Anexate) is a competitive benzodiazepine receptor antagonist that can be used as an antidote for benzodiazepine overdose. In particular, flumazenil is very effective at reversing the CNS depression associated with benzodiazepines but is less effective at reversing respiratory depression. Its use, however, is controversial as it has numerous contraindications. It is contraindicated in patients who are on long-term benzodiazepines, those who have ingested a substance that lowers the seizure threshold, or in patients who have tachycardia or a history of seizures. As a general rule, medical observation and supportive care are the mainstay of treatment of benzodiazepine overdose. Although benzodiazepines are absorbed by activated charcoal, gastric decontamination with activated charcoal is not beneficial in pure benzodiazepine overdose as the risk of adverse effects often outweigh any potential benefit from the procedure. It is recommended only if benzodiazepines have been taken in combination with other drugs that may benefit from decontamination. Gastric lavage (stomach pumping) or whole bowel irrigation are also not recommended. 2014-09-08T02:40:14Z 2026-08-21T23:50:00Z DB13643 true [H]\C(N1CCN(C)CC1)=C1\N=C2CN=C(C3=CC=CC=C3Cl)C3=C(C=CC(=C3)N(=O)=O)N2C1=O C23H21ClN6O3 InChI=1S/C23H21ClN6O3/c1-27-8-10-28(11-9-27)14-19-23(31)29-20-7-6-15(30(32)33)12-17(20)22(25-13-21(29)26-19)16-4-2-3-5-18(16)24/h2-7,12,14H,8-11,13H2,1H3/b19-14- UTEFBSAVJNEPTR-RGEXLXHISA-N 464.904 464.136366275 Exogenous Solid 2.68 CHEMBL2107448 2298440 CHEM003605 NS00015441 (4Z)-9-(2-chlorophenyl)-4-[(4-methylpiperazin-1-yl)methylidene]-12-nitro-2,5,8-triazatricyclo[8.4.0.0^{2,6}]tetradeca-1(10),5,8,11,13-pentaen-3-one 97.33000000000001 126.86799999999994 48.068009644575405 3 7 0 19.13464169919963 8.06004295325157 1 5 2.80 -3.71 9.17e-02 g/l Organic compounds Organoheterocyclic compounds Benzodiazepines 1,4-benzodiazepines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 776t3gAAAAAQAAAAAwAAAAAAAAAhAAAAJQAAAIABBgA4AAAAAwEEBwAoAAAA AwMGAGAAAAACAgYAYAAAAAICBwAgAAAAAwYAYAAAAAEDBgBgAAAAAgIGAGAA AAACAgYAKAAAAAMEBwAoAAAAAwMGACgAAAADBAYAYAAAAAICBwAoAAAAAwMG ACgAAAADBAZAKAAAAAMEBkBoAAAAAwMBBkBoAAAAAwMBBkBoAAAAAwMBBkBo AAAAAwMBBkAoAAAAAwQRACAAAAABBkAoAAAAAwQGQCgAAAADBAZAaAAAAAMD AQZAaAAAAAMDAQZAKAAAAAMEBkBoAAAAAwMBBwAqAAAAAQMECAAqAAAA/wMB CAAoAAAAAwIHACgAAAADAwYAKAAAAAMECAAoAAAAAwILAAEkAwECAAIDAAME AAQFAAQGAAYHAAAIKgICAgEJCAkkAwkKKAIKCwALDAAMDSgCDQ4gDg9oDA8Q aAwQEWgMERJoDBITaAwTFAANFSAVFmgMFhdoDBcYaAwYGWgMGRpoDBkbIBsc IBsdKAIWHiAeHyAfICgCBwEAHwggHgogEw5oDBoVaAxCBQAAAAYCAwQGBwEF CQgfHgoHCwoeFhUNDAYPEBESEw4GFxgZGhUWFwQAAAAAAAAAFg== 2026-09-19T04:01:25Z