<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">4768</id>
  <title>T3D4713</title>
  <common-name>Silica</common-name>
  <description>Silica is found in barley. The chemical compound silicon dioxide, also known as silica (from the Latin silex), is an oxide of silicon with a chemical formula of SiO2 and has been known for its hardness since antiquity. Silica is most commonly found in nature as sand or quartz, as well as in the cell walls of diatoms. Silica is the most abundant mineral in the Earth's crust.

Silica has been shown to exhibit immunosuppressant, hypocholesterolemic, anti-allergenic, anti-apoptotic and anti-histamine functions (A7884, A7885, A7886, A7887, A7886).

Silica belongs to the family of Metalloid Oxides. These are inorganic compounds containing an oxygen atom of an oxidation state of -2, in which the heaviest atom bonded to the oxygen is a metalloid.</description>
  <cas>7631-86-9</cas>
  <pubchem-id>24261</pubchem-id>
  <chemical-formula>O2Si</chemical-formula>
  <weight>60.084</weight>
  <appearance>White powder.</appearance>
  <melting-point>1716 - 1736 °C</melting-point>
  <boiling-point nil="true"/>
  <density nil="true"/>
  <solubility nil="true"/>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure></route-of-exposure>
  <target nil="true"/>
  <mechanism-of-toxicity></mechanism-of-toxicity>
  <metabolism></metabolism>
  <toxicity></toxicity>
  <lethaldose></lethaldose>
  <carcinogenicity>Crystalline silica in the form of quartz or cristobalite dust is carcinogenic to humans (Group 1). Amorphous silica is not classifiable as to its carcinogenicity to humans (Group 3). (L135)</carcinogenicity>
  <use-source></use-source>
  <min-risk-level></min-risk-level>
  <health-effects></health-effects>
  <symptoms></symptoms>
  <treatment></treatment>
  <created-at type="dateTime">2014-09-11T02:06:06Z</created-at>
  <updated-at type="dateTime">2026-05-14T19:07:14Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia>http://en.wikipedia.org/wiki/Silica</wikipedia>
  <uniprot-id></uniprot-id>
  <kegg-compound-id>C16459</kegg-compound-id>
  <omim-id></omim-id>
  <chebi-id>30563</chebi-id>
  <biocyc-id nil="true"/>
  <ctd-id></ctd-id>
  <stitch-id></stitch-id>
  <drugbank-id>DB11132</drugbank-id>
  <pdb-id nil="true"/>
  <actor-id></actor-id>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles>O=[Si]=O</moldb-smiles>
  <moldb-formula>O2Si</moldb-formula>
  <moldb-inchi>InChI=1S/O2Si/c1-3-2</moldb-inchi>
  <moldb-inchikey>VYPSYNLAJGMNEJ-UHFFFAOYSA-N</moldb-inchikey>
  <moldb-average-mass type="decimal">60.0843</moldb-average-mass>
  <moldb-mono-mass type="decimal">59.966755777</moldb-mono-mass>
  <origin>Exogenous</origin>
  <state>Solid</state>
  <logp>-0.66</logp>
  <hmdb-id>HMDB35659</hmdb-id>
  <chembl-id></chembl-id>
  <chemspider-id>22683</chemspider-id>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference nil="true"/>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM003671</chemdb-id>
  <dsstox-id>DTXSID1049770</dsstox-id>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id>NS00096378</susdat-id>
  <iupac>silanedione</iupac>
  <moldb-polar-surface-area>34.14</moldb-polar-surface-area>
  <moldb-refractivity>2.8858</moldb-refractivity>
  <moldb-polarizability>3.2811468900078617</moldb-polarizability>
  <moldb-rotatable-bond-count>0</moldb-rotatable-bond-count>
  <moldb-acceptor-count>2</moldb-acceptor-count>
  <moldb-donor-count>0</moldb-donor-count>
  <moldb-pka-strongest-acidic nil="true"/>
  <moldb-pka-strongest-basic>-8.532702804224158</moldb-pka-strongest-basic>
  <moldb-physiological-charge>0</moldb-physiological-charge>
  <moldb-number-of-rings>0</moldb-number-of-rings>
  <moldb-alogps-logp nil="true"/>
  <moldb-alogps-logs nil="true"/>
  <moldb-alogps-solubility nil="true"/>
  <kingdom>Inorganic compounds</kingdom>
  <superklass>Mixed metal/non-metal compounds</superklass>
  <klass>Metalloid organides</klass>
  <subklass>Metalloid oxides</subklass>
  <paper-count type="integer">403842</paper-count>
  <sync-id>CED0000531</sync-id>
</compound>
