4814 Liothyronine The L-triiodothyronine (T₃, liothyronine) thyroid hormone is normally synthesized and secreted by the thyroid gland in much smaller quantities than L-tetraiodothyronine (T₄, levothyroxine, L-thyroxine). Most T3 is derived from peripheral monodeiodination of T4 at the 5 position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. 6893-02-3 5920 C15H12I3NO4 White powder. 236-237°C 3.96 mg/L (at 37°C) 95% in 4 hours The hormones, T₄ and T₃, are tyrosine-based hormones produced by the thyroid gland. Iodine is an important component in their synthesis. The major form of thyroid hormone in the blood is thyroxine (T₄). This is converted to the more active liothyronine form by deiodinases in peripheral tissues. Liothyronine acts on the body to increase the basal metabolic rate, affect protein synthesis and increase the body's sensitivity to catecholamines (such as adrenaline). The thyroid hormones are essential to proper development and differentiation of all cells of the human body. To various extents T₄ and T₃ regulate protein, fat and carbohydrate metabolism. Their most pronounced effect is on how human cells use energetic compounds. The thyroid hormone derivatives bind to the thyroid hormone receptors initially to initiate their downstream effects. Half Life: 2.5 days No indication of carcinogenicity to humans (not listed by IARC). Used as replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyrodism during the recovery phase of subacute thyroiditis. 2014-09-11T05:15:14Z 2026-04-05T16:29:08Z Liothyronine C02465 18258 LIOTHYRONINE DB00279 T3 true N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O C15H12I3NO4 InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 650.9735 650.790038137 Exogenous Solid 2.9 HMDB00265 CHEMBL1544 5707 <p>Martin Beasley, David Hause, Irwin Klein, Charles Pamplin, David Reynolds, Kevin Sills, &#8220;Controlled release pharmaceutical compositions of liothyronine and methods of making and using the same.&#8221; U.S. Patent US20060246133, issued November 02, 2006.</p> CHEM003716 DTXSID8023216 NS00074206 (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid