5001 1-Methyl-2-pyrrolidone 1-Methyl-2-pyrrolidone, or N-Methyl-2-pyrrolidone (NMP), is a chemical compound with 5-membered lactam structure. It is a colorless to slightly yellow liquid miscible with water. It is used in petrochemical processing, and as a solvent for surface treatment of textiles, resins and metal coated plastics or as a paint stripper. In the pharmaceutical industry, N-methyl-2-pyrrolidone is used in the formulation for drugs by both oral and transdermal delivery routes. NMP has been identified as a reproductive toxicant, first by California in 2001[3] and then by the European Commission in 2003. In the face of increasing regulation, some manufacturers are considering alternative solvents for some applications, especially where worker exposure is difficult to control, such as in paint stripping, graffiti removal, and agriculture. (Wikipedia) 872-50-4 13387 C5H9NO 99.13 Colorless to slightly yellow liquid. -24°C 1-Methyl-2-pyrrolidone is rapidly biotransformed by hydroxylation to 5-hydroxy- N -methyl-2-pyrrolidone, which is further oxidized to N -methylsuccinimide; this intermediate is further hydroxylated to 2-hydroxy- N - methylsuccinimide. These metabolites are all colourless. The excreted amounts of NMP metabolites in the urine after inhalation or oral intake represented about 100% and 65% of the administered doses, respectively. No indication of carcinogenicity to humans (not listed by IARC). 1-Methyl-2-pyrrolidone is used in petrochemical processing, and as a solvent for surface treatment of textiles, resins and metal coated plastics or as a paint stripper. In the pharmaceutical industry, N-methyl-2-pyrrolidone is used in the formulation for drugs by both oral and transdermal delivery routes. Rapid, irregular respiration, shortnessof breath, decreased pain reflex, and slight bloody nasalsecretion. 2014-09-17T20:01:58Z 2026-04-17T19:29:27Z 13387 DB12521 true CN1CCCC1=O C5H9NO InChI=1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3 SECXISVLQFMRJM-UHFFFAOYSA-N 99.1311 99.068413915 Exogenous Liquid CHEMBL12543 12814 CHEM003902 DTXSID6020856 1-methylpyrrolidin-2-one