5581 <common-name>Nitric oxide</common-name> <description>Nitric oxide (NO) is a compound with an average molecular weight of 30.01 g/mol. Nitric oxide belongs to the other non-metal oxides, a subclass of other non-metal organides within the inorganic compounds. It is used in Polyamide and is found in unclassified respiratory system products within healthcare, pharmaceuticals, and veterinary products. Recorded exposure routes include topical and respiratory, with inhalation supported by literature (PMC11770536). Biologically, it serves as a neurotransmitter (PMC2745337, PMC9556195), inhibitor (PMC11429291), antimicrobial agent (PMC4160367, PMC6322413, PMC9465324), and biomarker (PMC6617305). It targets six proteins, including Nitric oxide synthase 3 (NOS3), Indoleamine 2,3-dioxygenase 1 (IDO1), Metallothionein-1A (MT1A), and Guanylate cyclase soluble subunit alpha-2 (GUCY1A2). The compound is associated with various health effects, including inflammation (PMC10837992, PMC11910329, PMC2885079, PMC3867356, PMC4739797), cancer (PMC3853740, PMC5362166, PMC9784116), rheumatoid arthritis (PMC3853740, PMC6264366), blood pressure (PMC11678264), thrombosis (PMC4739797), diabetic retinopathy (PMC3351417), pain (PMC9313384), methemoglobinemia (PMC1392223), and disease (PMC2929206). It is linked to an increase in asthma (PMC10948772), epilepsy (PMC4428026, PMC6213719), and interstitial cystitis (PMC3989437), as well as Hypogonadotropic hypogonadism (PMC13246832). Conversely, it is associated with a decrease in atherosclerosis (PMC2965309). Therapeutic effects are noted for hypertension (PMC4217569), glaucoma (PMC11013077), colon cancer (PMC3572206), and blood pressure (PMC13143078, PMC9479141), inflammation (PMC12988469, PMC6835591, PMC9479141), and thrombosis (PMC13143078, PMC6835591, PMC9479141). It is a treatment for thrombosis (PMC12194899). Additionally, it is a biomarker of inflammation (PMC13279942), asthma (PMC9170864), and liver cirrhosis (PMC12072035), and is increased in the blood of individuals with depression (PMC11563972).</description> <cas>10102-43-9</cas> <pubchem-id>145068</pubchem-id> <chemical-formula>NO</chemical-formula> <weight>30.006</weight> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2016-05-19T01:46:34Z</created-at> <updated-at type="dateTime">2026-05-14T16:38:40Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB00435</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>[N]=O</moldb-smiles> <moldb-formula>NO</moldb-formula> <moldb-inchi>InChI=1S/NO/c1-2</moldb-inchi> <moldb-inchikey>MWUXSHHQAYIFBG-UHFFFAOYSA-N</moldb-inchikey> <moldb-average-mass type="decimal">30.0061</moldb-average-mass> <moldb-mono-mass type="decimal">29.997988627</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp>-0.35</logp> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id nil="true"/> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM004476</chemdb-id> <dsstox-id>DTXSID1020938</dsstox-id> <toxcast-id nil="true"/> <stoff-ident-origin nil="true"/> <stoff-ident-id nil="true"/> <susdat-id>NS00076174</susdat-id> <iupac>nitroso</iupac> <moldb-polar-surface-area>34.14</moldb-polar-surface-area> <moldb-refractivity>2.8858</moldb-refractivity> <moldb-polarizability>1.6908497027346385</moldb-polarizability> <moldb-rotatable-bond-count>0</moldb-rotatable-bond-count> <moldb-acceptor-count>2</moldb-acceptor-count> <moldb-donor-count>0</moldb-donor-count> <moldb-pka-strongest-acidic nil="true"/> <moldb-pka-strongest-basic>-2.9121689657156256</moldb-pka-strongest-basic> <moldb-physiological-charge>0</moldb-physiological-charge> <moldb-number-of-rings>0</moldb-number-of-rings> <moldb-alogps-logp nil="true"/> <moldb-alogps-logs nil="true"/> <moldb-alogps-solubility nil="true"/> <kingdom>Inorganic compounds</kingdom> <superklass>Homogeneous non-metal compounds</superklass> <klass>Other non-metal organides</klass> <subklass>Other non-metal oxides</subklass> <paper-count type="integer">503636</paper-count> <sync-id>CED0000445</sync-id> <structure-inchikey>MWUXSHHQAYIFBG-UHFFFAOYSA-N</structure-inchikey> <structure-fingerprint>2000000000000000000000000000000000000000000000000000000000000000000000000000000000020000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000</structure-fingerprint> <structure-pattern-fingerprint>100000000000000000000000000000000000000000000000000010000000000000000000000000000000000000000000000000000400000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000020000000004000000000000000000000000000000000000000000080000000000004200000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000</structure-pattern-fingerprint> <structure-pickle>ï¾­Þ������������������������€�� ¨��������(����������B��������������</structure-pickle> <structure-indexed-at type="dateTime">2026-09-19T04:01:59Z</structure-indexed-at> </compound>