43789 <common-name>Spiramycin</common-name> <description>Spiramycin is an organic compound with the chemical formula C43H74N2O14. Spiramycin belongs to the carbohydrates and carbohydrate conjugates, a subclass of organooxygen compounds within the organic compounds. With an average molecular weight of 843.07 g/mol, Spiramycin is a heavy molecule. This compound is found in or released from three recorded sources: pharmaceuticals & veterinary products, specifically antibiotics, macrolides, lincosamides and streptogramins, and combinations of antibacterials. Recorded exposure routes for the substance include oral and inhalation. In terms of biological activity, Spiramycin acts as an inhibitor and antagonist of the Large ribosomal subunit protein uL3 (rplC).</description> <cas>8025-81-8</cas> <pubchem-id>6419898</pubchem-id> <chemical-formula>C43H74N2O14</chemical-formula> <weight nil="true"/> <appearance nil="true"/> <melting-point nil="true"/> <boiling-point nil="true"/> <density nil="true"/> <solubility nil="true"/> <specific-gravity nil="true"/> <flash-point nil="true"/> <vapour-pressure nil="true"/> <route-of-exposure nil="true"/> <target nil="true"/> <mechanism-of-toxicity nil="true"/> <metabolism nil="true"/> <toxicity nil="true"/> <lethaldose nil="true"/> <carcinogenicity nil="true"/> <use-source nil="true"/> <min-risk-level nil="true"/> <health-effects nil="true"/> <symptoms nil="true"/> <treatment nil="true"/> <created-at type="dateTime">2016-06-03T10:05:15Z</created-at> <updated-at type="dateTime">2026-04-14T16:01:35Z</updated-at> <interacting-proteins nil="true"/> <wikipedia nil="true"/> <uniprot-id nil="true"/> <kegg-compound-id nil="true"/> <omim-id nil="true"/> <chebi-id nil="true"/> <biocyc-id nil="true"/> <ctd-id nil="true"/> <stitch-id nil="true"/> <drugbank-id>DB06145</drugbank-id> <pdb-id nil="true"/> <actor-id nil="true"/> <organism nil="true"/> <export type="boolean">true</export> <metabolizing-proteins nil="true"/> <transporting-proteins nil="true"/> <moldb-smiles>COC1C(O)CC(=O)OC(C)CC=CC=CC(OC2CCC(C(C)O2)N(C)C)C(C)CC(CC=O)C1OC1OC(C)C(OC2CC(C)(O)C(O)C(C)O2)C(C1O)N(C)C</moldb-smiles> <moldb-formula>C43H74N2O14</moldb-formula> <moldb-inchi>InChI=1S/C43H74N2O14/c1-24-21-29(19-20-46)39(59-42-37(49)36(45(9)10)38(27(4)56-42)58-35-23-43(6,51)41(50)28(5)55-35)40(52-11)31(47)22-33(48)53-25(2)15-13-12-14-16-32(24)57-34-18-17-30(44(7)8)26(3)54-34/h12-14,16,20,24-32,34-42,47,49-51H,15,17-19,21-23H2,1-11H3</moldb-inchi> <moldb-inchikey>ACTOXUHEUCPTEW-UHFFFAOYSA-N</moldb-inchikey> <moldb-average-mass type="decimal">843.065</moldb-average-mass> <moldb-mono-mass type="decimal">842.514005071</moldb-mono-mass> <origin nil="true"/> <state nil="true"/> <logp nil="true"/> <hmdb-id nil="true"/> <chembl-id nil="true"/> <chemspider-id>4447664</chemspider-id> <structure-image-file-name nil="true"/> <structure-image-content-type nil="true"/> <structure-image-file-size type="integer" nil="true"/> <structure-image-updated-at type="dateTime" nil="true"/> <biodb-id nil="true"/> <synthesis-reference nil="true"/> <structure-image-caption nil="true"/> <chemdb-id>CHEM042684</chemdb-id> <dsstox-id>DTXSID6045402</dsstox-id> <toxcast-id nil="true"/> <stoff-ident-origin>Zweckverband Landeswasserversorgung Langenau</stoff-ident-origin> <stoff-ident-id>SI00000859</stoff-ident-id> <susdat-id>NS00000505</susdat-id> <iupac nil="true"/> <moldb-polar-surface-area>195.38</moldb-polar-surface-area> <moldb-refractivity>219.2458</moldb-refractivity> <moldb-polarizability>92.24500398215275</moldb-polarizability> <moldb-rotatable-bond-count>11</moldb-rotatable-bond-count> <moldb-acceptor-count>15</moldb-acceptor-count> <moldb-donor-count>4</moldb-donor-count> <moldb-pka-strongest-acidic>12.533481415187062</moldb-pka-strongest-acidic> <moldb-pka-strongest-basic>9.279546624831108</moldb-pka-strongest-basic> <moldb-physiological-charge>2</moldb-physiological-charge> <moldb-number-of-rings>4</moldb-number-of-rings> <moldb-alogps-logp>2.99</moldb-alogps-logp> <moldb-alogps-logs>-3.63</moldb-alogps-logs> <moldb-alogps-solubility>1.96e-01 g/l</moldb-alogps-solubility> <kingdom>Organic compounds</kingdom> <superklass>Organic oxygen compounds</superklass> <klass>Organooxygen compounds</klass> <subklass>Carbohydrates and carbohydrate conjugates</subklass> <paper-count type="integer">3905</paper-count> <sync-id>CED0004897</sync-id> <structure-inchikey>ACTOXUHEUCPTEW-UHFFFAOYSA-N</structure-inchikey> 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