<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">132681</id>
  <title nil="true"/>
  <common-name>GE-2270A</common-name>
  <description>GE-2270A is an organic compound with the formula C56H55N15O10S6. GE-2270A belongs to the macrolactams, a class of phenylpropanoids and polyketides within the organic compounds. With an average molecular weight of 1,291 g/mol, GE-2270A is a heavy molecule. This compound acts as an inhibitor of two recorded protein targets: Elongation factor 1-alpha (MEF-1) and Elongation factor Tu (tufA).</description>
  <cas>134861-34-0</cas>
  <pubchem-id nil="true"/>
  <chemical-formula>C56H55N15O10S6</chemical-formula>
  <weight nil="true"/>
  <appearance nil="true"/>
  <melting-point nil="true"/>
  <boiling-point nil="true"/>
  <density nil="true"/>
  <solubility nil="true"/>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure nil="true"/>
  <target nil="true"/>
  <mechanism-of-toxicity nil="true"/>
  <metabolism nil="true"/>
  <toxicity nil="true"/>
  <lethaldose nil="true"/>
  <carcinogenicity nil="true"/>
  <use-source nil="true"/>
  <min-risk-level nil="true"/>
  <health-effects nil="true"/>
  <symptoms nil="true"/>
  <treatment nil="true"/>
  <created-at type="dateTime">2026-04-13T22:05:01Z</created-at>
  <updated-at type="dateTime">2026-05-14T17:47:30Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia nil="true"/>
  <uniprot-id nil="true"/>
  <kegg-compound-id nil="true"/>
  <omim-id nil="true"/>
  <chebi-id nil="true"/>
  <biocyc-id nil="true"/>
  <ctd-id nil="true"/>
  <stitch-id nil="true"/>
  <drugbank-id>DB02975</drugbank-id>
  <pdb-id nil="true"/>
  <actor-id nil="true"/>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles>[H][C@]1(NC(=O)CNC(=O)C2=C(COC)SC(=N2)[C@@H](NC(=O)C2=C(C)SC(=N2)[C@H](CC(=O)NC)NC(=O)C2=CSC(=N2)C2=CC=C(N=C2C2=CSC(=N2)C2=CSC1=N2)C1=NC(=CS1)C1=N[C@@H](CO1)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](O)C1=CC=CC=C1</moldb-smiles>
  <moldb-formula>C56H55N15O10S6</moldb-formula>
  <moldb-inchi>InChI=1S/C56H55N15O10S6/c1-24(2)39-55-70-42(36(87-55)19-80-5)47(77)59-17-38(73)67-43(44(74)26-10-7-6-8-11-26)54-66-34(23-85-54)52-63-31(20-83-52)41-27(50-64-32(21-82-50)46(76)61-29(16-37(72)58-4)53-69-40(25(3)86-53)48(78)68-39)13-14-28(60-41)51-65-33(22-84-51)49-62-30(18-81-49)56(79)71-15-9-12-35(71)45(57)75/h6-8,10-11,13-14,20-24,29-30,35,39,43-44,74H,9,12,15-19H2,1-5H3,(H2,57,75)(H,58,72)(H,59,77)(H,61,76)(H,67,73)(H,68,78)/t29-,30-,35-,39-,43-,44-/m0/s1</moldb-inchi>
  <moldb-inchikey>JMDULECOHIXMNX-MZHFYNGJSA-N</moldb-inchikey>
  <moldb-average-mass type="decimal">1290.51</moldb-average-mass>
  <moldb-mono-mass type="decimal">1289.258060075</moldb-mono-mass>
  <origin nil="true"/>
  <state nil="true"/>
  <logp>4.27</logp>
  <hmdb-id nil="true"/>
  <chembl-id nil="true"/>
  <chemspider-id nil="true"/>
  <structure-image-file-name nil="true"/>
  <structure-image-content-type nil="true"/>
  <structure-image-file-size type="integer" nil="true"/>
  <structure-image-updated-at type="dateTime" nil="true"/>
  <biodb-id nil="true"/>
  <synthesis-reference nil="true"/>
  <structure-image-caption nil="true"/>
  <chemdb-id>CHEM128574</chemdb-id>
  <dsstox-id nil="true"/>
  <toxcast-id nil="true"/>
  <stoff-ident-origin nil="true"/>
  <stoff-ident-id nil="true"/>
  <susdat-id nil="true"/>
  <iupac>(2S)-1-[(4S)-2-{2-[(18S,25S,35S)-35-[(S)-hydroxy(phenyl)methyl]-28-(methoxymethyl)-21-methyl-18-[(methylcarbamoyl)methyl]-16,23,30,33-tetraoxo-25-(propan-2-yl)-3,13,20,27,37-pentathia-7,17,24,31,34,39,40,41,42,43-decaazaheptacyclo[34.2.1.1^{2,5}.1^{12,15}.1^{19,22}.1^{26,29}.0^{6,11}]tritetraconta-1(38),2(43),4,6,8,10,12(42),14,19(41),21,26(40),28,36(39)-tridecaen-8-yl]-1,3-thiazol-4-yl}-4,5-dihydro-1,3-oxazole-4-carbonyl]pyrrolidine-2-carboxamide</iupac>
  <moldb-polar-surface-area nil="true"/>
  <moldb-refractivity nil="true"/>
  <moldb-polarizability nil="true"/>
  <moldb-rotatable-bond-count nil="true"/>
  <moldb-acceptor-count nil="true"/>
  <moldb-donor-count nil="true"/>
  <moldb-pka-strongest-acidic nil="true"/>
  <moldb-pka-strongest-basic nil="true"/>
  <moldb-physiological-charge nil="true"/>
  <moldb-number-of-rings nil="true"/>
  <moldb-alogps-logp nil="true"/>
  <moldb-alogps-logs nil="true"/>
  <moldb-alogps-solubility nil="true"/>
  <kingdom>Organic compounds</kingdom>
  <superklass>Phenylpropanoids and polyketides</superklass>
  <klass>Macrolactams</klass>
  <subklass nil="true"/>
  <paper-count type="integer">25</paper-count>
  <sync-id>CED0028138</sync-id>
  <structure-inchikey>JMDULECOHIXMNX-MZHFYNGJSA-N</structure-inchikey>
  <structure-fingerprint>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</structure-fingerprint>
  <structure-pattern-fingerprint>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</structure-pattern-fingerprint>
  <structure-pickle>ï¾­Þ����������������W���a���€�� 4��������h��������(�������(�������`�������h��������(�������(������@(������@(�������`������� ������`������@(������@(������@(������ 4��������h��������(�������(������@(������@(�������`������@(������@(������@(������ 4��������`�������(�������(�������h��������`�������h��������(�������(������@(������@h�������@(������@(������@(������@(������@h�������@h�������@(������@(������@(������@(������@h�������@(������@(������@(������@(������@h�������@(������@(������@(������@(������@(������@(������@h�������@(�������(�������(������ 4��������`�������(�������(�������(�������(�������`�������`�������`������ 4��������(�������h��������(�������`�������`�������`������ 4��������`������@(������@h�������@h�������@h�������@h�������@h������������ ��(��������� ��(��� �	h�	
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�����	h��h���h��������� ��(��� ��h������h���h���h������������(��� ���� � ! !"(�!# #$h�$%h�%&amp;h�&amp;'h�&amp;( ()h�)*h�*+h�+,h�,-h�-. ./h�/0h�01h�12h�13 34h�45h�56h�67h�+8 89h�9:h�:;h�;&lt;h�:= =&gt;(�&gt;?�?@�@A�?B�BC(�BD DE�EF�FG�GH�HI�IJ IK(��L�LM�LN��O�OP�OQ�QRh�RSh�STh�TUh�UVh�6��&lt;8h�A= HD�VQh���h���h�'#h�-(h�2.h�73h�B�������67312.-(&amp;'#! ���������������	����������$#'&amp;%�)*+,-(�/.210�43765�98&lt;;:�&gt;=A@?�EDHGF�RSTUVQ����������</structure-pickle>
  <structure-indexed-at type="dateTime">2026-09-19T04:49:06Z</structure-indexed-at>
</compound>
