ContaminantDB: Cobalt(II) succinate

Identification Taxonomy Biological Properties Physical Properties Toxicity Profile Spectra Concentrations Links References Targets (60)XML

Record Information

Version

1.0

Creation Date

2009-06-19 21:58:44 UTC

Update Date

2026-04-05 19:40:56 UTC

Accession Number

CHEM001204

Identification

Common Name

Cobalt(II) succinate

Class

Small Molecule

Description

Cobalt(II) succinate is an exogenous solid compound with the formula C4H4CoO4 and an average molecular weight of 175.01 g/mol. Cobalt(II) succinate belongs to the dicarboxylic acids and derivatives, a subclass of carboxylic acids and derivatives within the organic compounds. The compound exhibits a wide range of biological interactions across 22 recorded protein targets. It inhibits heme synthesis by preventing the synthesis of 5-aminolaevulinate through the inhibition of 5-aminolevulinate synthase, both the erythroid-specific mitochondrial (ALAS2) and non-specific mitochondrial (ALAS1) forms. Additionally, cobalt inhibits carbonic anhydrases, specifically Carbonic anhydrase 1 (CA1), Carbonic anhydrase 2 (CA2), and Carbonic anhydrase 4 (CA4). It interferes with DNA repair by interacting with zinc finger DNA repair proteins, including Poly [ADP-ribose] polymerase 1 (PARP1). Furthermore, cobalt blocks high-voltage-activated calcium channels, which may impair neurotransmission; associated targets include the Voltage-dependent calcium channel gamma-1 subunit (CACNG1), Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1), Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2), Voltage-dependent calcium channel subunit alpha-2/delta-3 (CACNA2D3), and 10 other proteins. Cobalt also interacts with specific antibodies, resulting in immunosensitization through interactions with Immunoglobulin heavy constant alpha 1 (IGHA1), Immunoglobulin heavy constant alpha 2 (IGHA2), and specific IgE antibodies. Finally, radioactive cobalt is capable of damaging lipids, RNA, and DNA through ionizing events.

Contaminant Sources

IARC Carcinogens Group 2B
T3DB toxins

Contaminant Type

Cobalt Compound
Industrial/Workplace Toxin
Organic Compound
Organometallic
Pollutant
Synthetic Compound

Chemical Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
Cobalt(II) succinic acid	Generator

Chemical Formula

C₄H₄CoO₄

Average Molecular Mass

175.005 g/mol

Monoisotopic Mass

174.944 g/mol

CAS Registry Number

3267-76-3

IUPAC Name

Not Available

Traditional Name

λ²-cobalt(2+) ion succinate

SMILES

[Co++].[O-]C(=O)CCC([O-])=O

InChI Identifier

InChI=1S/C4H6O4.Co/c5-3(6)1-2-4(7)8;/h1-2H2,(H,5,6)(H,7,8);/q;+2/p-2

InChI Key

XENHXPKUQLUHCZ-UHFFFAOYSA-L

Chemical Taxonomy

Description

belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Dicarboxylic acids and derivatives

Direct Parent

Dicarboxylic acids and derivatives

Alternative Parents

Substituents

Fatty acid
Dicarboxylic acid or derivatives
Carboxylic acid salt
Organic transition metal salt
Carboxylic acid
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organic cobalt salt
Organic salt
Organooxygen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

Not Available

Biological Properties

Status

Detected and Not Quantified

Origin

Exogenous

Cellular Locations

Cytoplasm
Extracellular

Biofluid Locations

Not Available

Tissue Locations

Not Available

Pathways

Not Available

Applications

Not Available

Biological Roles

Not Available

Chemical Roles

Not Available

Physical Properties

State

Solid

Appearance

White powder.

Experimental Properties

Property	Value
Melting Point	Not Available
Boiling Point	Not Available
Solubility	Slightly soluble in cold water; soluble in alkalies; insoluble in alcohol.

Predicted Properties

Property	Value	Source
Water Solubility	35.2 g/L	ALOGPS
logP	0.52	ALOGPS
logP	-0.4	ChemAxon
logS	-0.81	ALOGPS
pKa (Strongest Acidic)	3.55	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	80.26 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	45.21 m³·mol⁻¹	ChemAxon
Polarizability	9.33 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	1	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

Spectrum Type	Description	Splash Key	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0kl0-4900000000-043666fb2509336a4d98	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0kpi-9600000000-ebffdf2ccc0d0a030724	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-004i-9000000000-d45f8de3e02b65b7f909	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00dj-9600000000-1f990a48d4ff62f21ef9	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00dj-9300000000-7c18e82f3139ed199659	Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0l6s-9000000000-09e4028c978572f3fb3d	Spectrum

Toxicity Profile

Route of Exposure

Inhalation (2) ; oral (2) ; dermal (2)

Mechanism of Toxicity

Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (2)

Metabolism

Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (2)

Toxicity Values

Not Available

Lethal Dose

Not Available

Carcinogenicity (IARC Classification)

2B, possibly carcinogenic to humans. (5)

Uses/Sources

Not Available

Minimum Risk Level

Chronic Inhalation: 0.0001 mg/m3 (4) Intermediate Oral: 0.01 mg/kg/day (4)

Health Effects

Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitis. Cobalt may also have mutagenic and carcinogenic effects. (2, 3)

Symptoms

Cobalt inhalation can cause asthma-like breathing problems. Skin contact is known to result in contact dermatitis, which is characterized by irritation and rashes. Ingesting large amounts of cobalt may cause nausea and vomiting. (6)

Treatment

Treatment of cobalt poisoning is symptomatic. (2)

Concentrations

Not Available

External Links

DrugBank ID

Not Available

HMDB ID

Not Available

FooDB ID

Not Available

Phenol Explorer ID

Not Available

KNApSAcK ID

Not Available

BiGG ID

Not Available

BioCyc ID

Not Available

METLIN ID

Not Available

PDB ID

Not Available

Wikipedia Link

Not Available

Chemspider ID

Not Available

ChEBI ID

Not Available

PubChem Compound ID

18633

Kegg Compound ID

Not Available

YMDB ID

Not Available

ECMDB ID

Not Available

References

Synthesis Reference

Not Available

MSDS

Not Available

General References

Not Available

Cobalt(II) succinate (CHEM001204)

Structure for CHEM001204: Cobalt(II) succinate