Potassium hexachloro-palladate(IV) (CHEM001359)

IdentificationTaxonomyBiological PropertiesPhysical PropertiesToxicity ProfileSpectraConcentrationsLinksReferencesTargets (31)XML
Record Information
Version1.0
Creation Date2009-06-19 21:59:00 UTC
Update Date2026-04-05 20:23:05 UTC
Accession NumberCHEM001359
Identification
Common NamePotassium hexachloro-palladate(IV)
ClassSmall Molecule
DescriptionPotassium hexachloro-palladate(IV) is an exogenous inorganic compound with the formula Cl6K2Pd and an average molecular weight of 397.33 g/mol. At room temperature, this compound exists as a solid. Potassium hexachloro-palladate(IV) belongs to the alkali metal chlorides, a subclass of alkali metal salts within the inorganic compounds. It is classified as a mixed metal/non-metal compound. The compound is found in or released from one recorded source: fermentation processes for beer used in food, food processing, and cookware. Potassium hexachloro-palladate(IV) interacts with four recorded protein targets. It inhibits creatine kinase M-type (CKM) by forming a complex with its essential SH groups. Additionally, it irreversibly inhibits transmembrane prolyl 4-hydroxylase (P4HTM), prolyl 4-hydroxylase subunit alpha-1 (P4HA1), and prolyl 4-hydroxylase subunit alpha-2 (P4HA2) by replacing Fe2+ in the active site to form a strong complex with the enzyme.
Contaminant Sources
  • T3DB toxins
Contaminant Type
  • Industrial/Workplace Toxin
  • Inorganic Compound
  • Palladium Compound
  • Synthetic Compound
Chemical Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
Potassium hexachloro-palladic acid(IV)Generator
Chemical FormulaCl6K2Pd
Average Molecular Mass397.330 g/mol
Monoisotopic Mass393.644 g/mol
CAS Registry Number10025-98-6
IUPAC NameNot Available
Traditional Namedipotassium hexachloropalladate(2-)
SMILES[K+].[K+].Cl[Pd--](Cl)(Cl)(Cl)(Cl)Cl
InChI IdentifierInChI=1S/6ClH.2K.Pd/h6*1H;;;/q;;;;;;2*+1;+4/p-6
InChI KeyOEDRXJBJMMJUSV-UHFFFAOYSA-H
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as alkali metal chlorides. These are inorganic compounds in which the largest halogen atom is Chlorine, and the heaviest metal atom is an alkali metal.
KingdomInorganic compounds
Super ClassMixed metal/non-metal compounds
ClassAlkali metal salts
Sub ClassAlkali metal chlorides
Direct ParentAlkali metal chlorides
Alternative Parents
Substituents
  • Alkali metal chloride
  • Inorganic chloride salt
  • Inorganic salt
Molecular FrameworkNot Available
External DescriptorsNot Available
Biological Properties
StatusDetected and Not Quantified
OriginExogenous
Cellular Locations
  • Cytoplasm
  • Extracellular
Biofluid LocationsNot Available
Tissue LocationsNot Available
PathwaysNot Available
ApplicationsNot Available
Biological RolesNot Available
Chemical RolesNot Available
Physical Properties
StateSolid
AppearanceWhite powder.
Experimental Properties
PropertyValue
Melting PointNot Available
Boiling PointNot Available
SolubilityNot Available
Predicted Properties
PropertyValueSource
logP3.81ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity36.82 m³·mol⁻¹ChemAxon
Polarizability17.23 ųChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0006-0009000000-21e7fa46c1678a127edbSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0006-0009000000-e5c22c9f4980619f139eSpectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-2009000000-368fb0077e676e8d409bSpectrum
Toxicity Profile
Route of ExposureNot Available
Mechanism of ToxicityDue to their ability to form strong complexes with both inorganic and organic ligands, palladium ions can disturb cellular equilibria, replace other essential ions, and interact with functional groups of macromolecules, such as proteins or DNA. Palladium complexes binding to DNA and RNA leads to strand breakage. Palladium ions are able to inhibit most major cellular functions, including DNA and RNA synthesis. Palladium compounds have been shown to bind to and inhibit various enzymes, including creatine kinase and prolyl hydroxylase. (3)
MetabolismPalladium may be absorbed through oral, dermal, and inhalation exposure. Once in the body it distributes to the kidney, liver, spleen, lymph nodes, adrenal gland, lung and bone. Palladium's ability to form complexes allows it the bind to amino acids, proteins, DNA, and other macromolecules. Palladium and its metabolites are excreted in the urine and faeces. (1)
Toxicity ValuesNot Available
Lethal DoseNot Available
Carcinogenicity (IARC Classification)No indication of carcinogenicity to humans (not listed by IARC).
Uses/SourcesNot Available
Minimum Risk LevelNot Available
Health EffectsContact with palladium may cause palladium sensitivity and allergy. Animal studies have shown that palladium may damage the liver and kidney. (3)
SymptomsSkin contact with palladium may cause contact dermatitis, erythema, and oedema. (3)
TreatmentNot Available
Concentrations
Not Available
DrugBank IDNot Available
HMDB IDNot Available
FooDB IDNot Available
Phenol Explorer IDNot Available
KNApSAcK IDNot Available
BiGG IDNot Available
BioCyc IDNot Available
METLIN IDNot Available
PDB IDNot Available
Wikipedia LinkNot Available
Chemspider IDNot Available
ChEBI IDNot Available
PubChem Compound IDNot Available
Kegg Compound IDNot Available
YMDB IDNot Available
ECMDB IDNot Available
References
Synthesis ReferenceNot Available
MSDSNot Available
General ReferencesNot Available